As with most drugs, DMT can affect people in very different ways. Some truly enjoy the experience. Others find it overwhelming or frightening.
As far as its psychoactive effects, people have described feeling like they’re traveling at warp speed through a tunnel of bright lights and shapes. Others describe having an out-of-body experience and feeling like they’ve changed into something else.
There are also some who report visiting other worlds and communicating with elf-like beings.
Some people also report a pretty rough comedown from DMT that leaves them feeling unsettled.
Synthetic DMT usually comes in the form of a white, crystalline powder. It can be smoked in a pipe, vaporized, injected, or snorted.
When used in religious ceremonies, plants and vines are boiled to create a tea-like drink of varying strengths.
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Synthetic DMT kicks in pretty fast, producing effects within 5 to 10 minutes.
Plant-based brews tend to produce effects within 20 to 60 minutes.
The intensity and duration of a DMT trip depends on several things, including:
- how much you use
- how you use it
- whether you’ve eaten
- whether you’ve taken other drugs
Generally, the effects of inhaled, snorted, or injected DMT last for about 30 to 45 minutes.
Drinking it in a brew like ayahuasca can leave you tripping for anywhere from 2 to 6 hours.
DMT has no approved medical use in the United States. but can be used by researchers under a Schedule I research registration that requires approval from both the Drug Enforcement Administration (DEA) and the Food and Drug Administration (FDA).
Despite its illegal status, DMT is used in some religious ceremonies and various settings for an “awakening” or to obtain deep spiritual insight.
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Fast facts on DMT
Here are some key points about DMT. More detail and supporting information is in the main article.
- DMT has been used as a drug for thousands of years.
- Use of the drug as part of shamanic ritual is common in South America.
- Side effects include powerful hallucinations.
- Due to the nature of the drug, DMT is known as the “spirit molecule.”
DMT is a white crystalline powder that is derived from certain plants found in Mexico, South America, and parts of Asia, such as Psychotria viridis and Banisteriopsis caapi.
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It is typically consumed in the following ways:
- vaporized or smoked in a pipe
- consumed orally in brews like ayahuasca
- snorted or injected on rare occasions
The chemical root structure of DMT is similar to the anti-migraine drug sumatriptan, and it acts as a non-selective agonist at most or all of the serotonin receptors, particularly at the serotonin 5-ht2a receptor. Serotonin is a neurotransmitter that has a large effect on the majority of our brain cells.
There is some evidence that DMT is also produced endogenously, in other words, it is produced naturally in the body, specifically in the pineal gland in the brain.
When smoked, the average dose of DMT is believed to be somewhere between 30 to 150 milligrams (mg), and the onset of action can be felt almost instantly. The effects peak and plateau for 3 to 5 minutes, and gradually drop off with the duration of effect totaling 30 to 45 minutes.